SAB3500952

Anti-IL-37 antibody produced in rabbit

affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA; IF; IHC
• クローン: polyclonal
• 化学種の反応性: human
• citations: 6
• テクニック: ELISA: suitable; immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: predicted mol wt 24 kDa
• 化学種の反応性: human
• 濃度: 1 mg/mL
• テクニック: ELISA: suitable; immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• NCBIアクセッション番号: NP_055254
• UniProtアクセッション番号: Q9NZH6
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... IL37(27178)

詳細

詳細

IL-37 (interleukin 37) is an anti-inflammatory cytokine and is also termed as IL-1 family member 7 (IL-1F7). IL-37 belongs to the IL-1 cytokine family. This protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells. IL-37 is located on human chromosome 2q12.

免疫原

Antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.

生物化学的／生理学的作用

IL-37 (interleukin 37) acts as a suppressor for innate immunity and acquired immunity. IL-37 participates in the immunosuppressive property of human CD4⁺CD25⁺ regulatory T cells. It represses the synthesis of several pro-inflammatory cytokines like IL-1α, IL-1β, IL-6, IL-12, granulocyte colony-stimulating factor (G-SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α (tumor necrosis factor alpha). It plays an important role in adaptive immunity.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

関連事項

The action of this antibody can be blocked using blocking peptide SBP3500952.

物理的形状

1 mg/mLのPBS溶液（0.02％アジ化ナトリウム含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable