おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
rat, mouse, human
テクニック
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... SIRPA(140885)
詳細
Signal regulatory protein α (SIRPα) is expressed in dendritic cells and macrophages. It is a cell-surface protein. The protein possesses a highly glycosylated extracellular region, three immunoglobin superfamily domains and an intracellular domain with immunoreceptor tyrosine-based inhibitory motifs. The gene encoding SIRPα is localized on human chromosome 20p13.
免疫原
SIRP alpha antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1? The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.
生物化学的／生理学的作用
Signal regulatory protein α (SIRPα) acts as a modulator of immune responses. It has a role in the migration, adhesion, growth and differentiation of cells. SIRPα associates with cluster of differentiation 47 (CD47) and prevents phagocytosis by macrophages.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500202.
物理的形状
PBS（0.02％ アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
On the origins of adaptive immunity: innate immune receptors join the tale.
van den Berg T K, et al.
Trends in Immunology, 25(1), 11-16 (2004)
Signal regulatory protein a associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages.
Ye X, et al.
Oncotarget, 79(49), 81305-81305 (2016)
Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.
Irandoust M, et al.
PLoS ONE, 8(1), e52143-e52143 (2013)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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