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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
mouse, human
テクニック
ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 500-3000
NCBIアクセッション番号
UniProtアクセッション番号
アプリケーション
research pathology
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... GPC1(2817)
詳細
Glypican 1 (GPC1) is located at 2q37.3 on the human chromosome. It belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. GPC1 is localized in the vascular system. GPC1 consists of an N-terminal secretory signal peptide, 14 conserved cysteine residues, a heparan sulfate (HS) attachment domain near the C terminus and a hydrophobic domain for attachment of the glycosylphosphatidylinositol (GPI) at the C terminus.
免疫原
Recombinant protein encompassing a sequence within the center region of human Glypican 1.
アプリケーション
Anti-GPC1 antibody produced in rabbit has been used in flow cytometry and immunostaining.
生物化学的／生理学的作用
Glypican 1 (GPC1) plays an important role in cell growth, differentiation and morphogenesis. It also plays a role in cell migration, adhesion, anti-coagulation, lipoprotein metabolism and modulation of growth factors. GPC1 exhibits chaperone-like activity by restoring the binding activity of oxidized VEGF165 (vascular endothelial growth factors-165). Overexpression of GPC1 results in over accumulation of β-amyloid protein (Aβ) in the Alzheimer′s disease (AD) brain. Mutation in this gene is associated with Niemann-Pick C1 disease.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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シグナルワード
Warning
危険有害性情報
危険有害性の分類
Aquatic Chronic 3 - Skin Sens. 1
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB2700282-100UL:
SAB2700282-100UG:
最新バージョンのいずれかを選択してください：
Characterization of Slit protein interactions with glypican-1
Ronca F, et al.
Test, 276(31), 29141-29147 (2001)
Glypican-1 as an Abeta binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer?s disease
Watanabe N, et al.
Faseb Journal, 18(9), 1013-1015 (2004)
Molecular delineation of deletions on 2q37. 3 in three cases with an Albright hereditary osteodystrophy-like phenotype
Shrimpton A E, et al.
Clinical Genetics, 66(6), 537-544 (2004)
Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1
Svensson G, et al.
The Journal of biological chemistry, 287(17), 14040-14051 (2012)
Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
Gengrinovitch S, et al.
Test, 274(16), 10816-10822 (1999)
Global Trade Item Number
| カタログ番号 | GTIN |
|---|---|
| SAB2700282-100UG | |
| SAB2700282-100UL | 4061837267932 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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