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由来生物
goat
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
human
テクニック
ELISA: suitable
western blot: suitable
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TACSTD2(4070)
詳細
Tumor associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell surface antigen 2 (TROP2), is a 36 kDa protein and part of the TACSTD family. The gene encoding this cell surface glycoprotein is localized on human chromosome 1p32.1.
免疫原
NP_002344.2によるタンパク質配列の内部領域に由来するペプチド(C-HYEQPTIQIELRQN)。
生物化学的／生理学的作用
Trophoblast cell surface antigen 2 (TROP2) has a role in epithelial-mesenchymal transition. It modulates stem cell activity and is crucial in promoting cell self-renewal and survival. TROP2 increases intracellular calcium levels. The protein is overexpressed in many cancers. It has been shown to influence the proliferation and migration of gallbladder cancer cells.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
Tris緩衝生理食塩水(0.5% BSA, 0.02%アジ化ナトリウム含有)の0.5 mg/mL溶液。
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シグナルワード
Warning
危険有害性情報
危険有害性の分類
Eye Irrit. 2 - Skin Irrit. 2
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Overexpression of trophoblast cell surface antigen 2 as an independent marker for a poor prognosis and as a potential therapeutic target in epithelial ovarian carcinoma.
Xu N,et al.
International Journal of Experimental Pathology, 97(2), 150-158 (2016)
TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT.
Li X, et al.
Oncotarget, 8(29), 47052-47052 (2017)
TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity.
Fong D, et al.
Modern Pathology, 21(2), 186-186 (2008)
Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease.
Liu Q, et al.
Respiratory Research, 17(1), 159-159 (2016)
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