由来生物
rabbit
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
21 kDa
交差性
bovine, human, dog, pig
濃度
0.5-1 mg/mL
テクニック
immunoblotting: suitable
immunohistochemistry: suitable
アクセッション番号
NM_138761
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... BAX(581)
詳細
B-cell lymphoma 2 associated X (BAX), also known as CLECSF10 (C-type lectin superfamily member 10), is located on human chromosome 19q13. BAX is a proapoptotic protein and is a member of Bcl-2 protein family.
免疫原
Synthetic peptide directed towards the N terminal region of human BAX
アプリケーション
Anti-BAX has been used in Western blotting.
生物化学的/生理学的作用
B-cell lymphoma 2 associated X (BAX) promotes cell death and plays a vital role in regulation of apoptosis. BAX gene may act as a negative regulator of autophagy in CRC (colorectal cancer) development.
シーケンス
Synthetic peptide located within the following region: MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPV
物理的形状
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB2108447-100UL:
最新バージョンのいずれかを選択してください:
Enhanced radiation effect on SMCC7721 cells through endoplasmic reticulum stress induced by C225-GNPs in vitro and in vivo
Zhu C, et al.
Oncology Letters, 15, 4221-4228 (2018)
Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL
Luciano F, et al.
The Journal of Biological Chemistry, 280, 15825-15835 (2005)
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.
Selvakumaran M, et al.
Oncogene, 9, 1791-1798 (1994)
The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer
Gil J, et al.
Medical Oncology (Northwood, London, England), 34 (2017)
The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria.
Simonyan L, et al.
Biochimica et Biophysica Acta, 1859, 1144-1155 (2017)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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