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由来生物
mouse
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
X1, monoclonal
フォーム
buffered aqueous solution
分子量
antigen 44.99 kDa
交差性
human
テクニック
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
アイソタイプ
IgG1κ
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... FTL(2512)
詳細
Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. This gene encodes the light subunit of the ferritin protein. It is composed of 24 subunits of the heavy and light ferritin chains.(provided by RefSeq). In humans, the heavy H and the light L chains are made up of 183 and 175 amino acids, respectively. FTL (ferritin) is a heteropolymer, located on human chromosome 19q13. Ferritins centralize iron in their inner compartment as a bioavailable iron oxide biomineral.
免疫原
FTL (AAH04245, 1 a.a. ~ 175 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
Sequence
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKREGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSARTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
生物化学的／生理学的作用
Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
L-Ferritin subunits deliver the scaffold for a trinuclear peroxo-bridged cluster.
L-Ferritin subunits deliver the scaffold for a trinuclear peroxo-bridged cluster.
物理的形状
無色透明のPBS溶液、pH 7.4
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB1409054-100UG:
最新バージョンのいずれかを選択してください：
Chemistry at the protein?mineral interface in L-ferritin assists the assembly of a functional (?3-oxo) Tris [(?2-peroxo)] triiron (III) cluster.
Pozzi C, et al.
Proceedings of the National Academy of Sciences of the USA, 114(10), 2580-2585 (2017)
A novel double nucleotide variant in the ferritin-L iron-responsive element in a Finnish patient with hereditary hyperferritinaemia-cataract syndrome
Mattila, et al.
Acta Ophthalmologica, 96(1), 95-99 (2018)
Bjoern Tews et al.
International journal of cancer, 119(4), 792-800 (2006-03-22)
Loss of heterozygosity (LOH) on chromosomal arms 1p and 19q is the most common genetic alteration in oligodendroglial tumors and associated with response to radio- and chemotherapy as well as favorable prognosis. Using microsatellite analysis, we previously identified the chromosomal
Shuping Zhang et al.
Cellular signalling, 26(11), 2539-2550 (2014-08-06)
Iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including cancers. Burgeoning evidence indicates that the central signaling of iron homeostasis, the
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