おすすめの製品
由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~37.1 kDa
交差性
human
テクニック
flow cytometry: suitable
western blot: 1 μg/mL
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... MRGPRX2(117194)
関連するカテゴリー
詳細
Mas-related G protein-coupled receptor X2 (MRGPRX2) belonging to the class A GPCR/Mas-related gene family is expressed in sensory neurons, mast cells, and keratinocytes. It has seven transmembrane (TM) α-helices. MRGPRX2 mRNA is found at a high level in the skin. It is also detected in adipose tissue, esophagus, urinary bladder, and lungs. MRGPRX2 gene with two-exon is mapped on human chromosome 11p15.
免疫原
MRGPRX2 (NP_473371.1, 1 a.a. ~ 330 a.a) full-length human protein.
Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
Sequence
MDPTTPAWGTESTTVNGNDQALLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV
生物化学的／生理学的作用
Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast cells acts as an important receptor for pseudo-allergic responses induced by drugs. It is involved in the evolution of the human nervous system. It is also crucial to mast cells. MRGPRX2 gene mutation impairs the risk of anaphylactic actions facilitated by the MRGPRX2 receptor.
物理的形状
無色透明のPBS溶液、pH 7.4
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Haihui Wu et al.
Progress in histochemistry and cytochemistry, 50(1-2), 11-17 (2015-06-25)
Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is
Chalatip Chompunud Na Ayudhya et al.
International journal of molecular sciences, 22(10) (2021-06-03)
The neuropeptide substance P (SP) mediates neurogenic inflammation and pain and contributes to atopic dermatitis in mice through the activation of mast cells (MCs) via Mas-related G protein-coupled receptor (GPCR)-B2 (MrgprB2, human ortholog MRGPRX2). In addition to G proteins, certain
Di Wei et al.
Immunopharmacology and immunotoxicology, 43(1), 77-84 (2020-12-18)
Clozapine is one of the most widely used second-generation antipsychotics in clinic. However, allergy-like symptoms such as rash and angioedema have been reported frequently, and the mechanism is still not clear. Mas-related G protein-coupled receptor X2 (MRGPRX2) expressed on mast
Global Trade Item Number
| カタログ番号 | GTIN |
|---|---|
| SAB1408259-50UG | 4061835696963 |
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