SAB1303565
ANTI-ADAMTS13 (CENTER) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
別名:
A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, ADAMTS13, C9orf8, vWF-CP, vWF-cleaving protease, von Willebrand factor-cleaving protease
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すべての画像(1)
About This Item
UNSPSCコード:
12352203
NACRES:
NA.41
おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
153604 Da
交差性
human
テクニック
immunohistochemistry: 1:50-1:100
western blot: 1:250-1:500
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ADAMTS13(11093)
詳細
A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13 (ADAMTS13) also known as von willebrand factor-cleaving protease (VWFCP), has distinct regions like a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 domain and spacer domain rich in cysteine residues. ADAMST13 is highly expressed in the liver and secreted as an active enzyme in the blood. In human chromosome, the gene ADAMTS13 is localised on 9q34.
生物化学的／生理学的作用
A disintegrin-like and metalloprotease with thrombospondin type 13 (ADAMTS13) cleaves von Willebrand factor (VWF) and thereby controls platelet thrombus formation. ADAMTS13 requires zinc, and calcium for its effective catalytic activity. Mutations in ADAMTS13 can lead to life threatening acquired thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome. Congenital deficiency of ADAMTS13 leads to Upshaw−Schulman syndrome.
物理的形状
精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）この抗体は、プロテインAカラムろ過後にペプチドアフィニティカラムで精製されます。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure
Shibagaki Y, et al.
Nephrology, Dialysis, and Transplantation, 21(5), 1289-1292 (2006)
Zinc and calcium ions cooperatively modulate ADAMTS13 activity
Anderson PJ, et al.
The Journal of Biological Chemistry, 281(2), 850-857 (2006)
A functional calcium-binding site in the metalloprotease domain of ADAMTS13
Gardner MD, et al.
Blood, 113(5), 1149-1157 (2009)
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Levy GG, et al.
Nature, 413(6855), 488-488 (2001)
Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
Akiyama M, et al.
Proceedings of the National Academy of Sciences of the USA, 106(46), 19274-19279 (2009)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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