おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
saturated ammonium sulfate (SAS) precipitated
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
human
テクニック
flow cytometry: suitable
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ABCB5(340273)
詳細
ABCB5 (ATP binding cassette subfamily B member 5) gene is located in human chromosome 7p21.1. The encoded protein belongs to the subfamily B multidrug resistance and ATP-binding cassette superfamily of active transporters. The encoded protein have two identical halves, each contains a hydrophobic region with six transmembrane segments and a nucleotide-binding region. Expression of this gene is observed in prostate and testis and in human melanoma tumor-initiating cells.
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules.
免疫原
ABCB5 (NP_848654, 3-35)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ABCB5.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ABCB5.
アプリケーション
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)
Flow cytometry/Cell sorting (1 paper)
生物化学的／生理学的作用
ABCB5 (ATP binding cassette subfamily B member 5) is a cell surface marker for melanoma-initiating cells, on cellular metabolism. ABCB5 significantly regulates glycolysis, glutaminolysis and phospholipid metabolism. It induces stem cell differentiation, stem cell immortality and anti-apoptotic activity. The gene is upregulated in many cancer subtypes, including breast cancer. Recent studies reveal that ABCB5 is a novel marker for limbal stem cell and is needed for corneal development and repair. ABCB5 shows resistance against taxanes and anthracyclines, the anti-cancer drugs.
物理的形状
精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Juntao Yao et al.
Oncology research, 25(3), 305-316 (2017-03-11)
ABCB5 belongs to the ATP-binding cassette (ABC) superfamily, which is recognized for playing a role in the failure of chemotherapy. ABCB5 has also been found to be overexpressed at the transcriptional level in a number of cancer subtypes, including breast
Shingo Kondo et al.
BMC pharmacology & toxicology, 16, 37-37 (2015-12-17)
Previously, we have demonstrated that human ABCB5 is a full-sized ATP-binding cassette transporter that shares strong homology with ABCB1/P-glycoprotein. ABCB5-transfected cells showed resistance to taxanes and anthracyclines. Herein, we further screened ABCB5 substrates, and explored the mechanism of resistance. Sensitivity
Passara Jongkhajornpong et al.
Scientific reports, 6, 20541-20541 (2016-02-05)
ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal homeostasis. ABCB5 expression has also been
Norbert W Lutz et al.
PloS one, 11(8), e0161803-e0161803 (2016-08-26)
We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for two groups of human G3361 melanoma cells were compared
Michiko Akiyama et al.
Oncology letters, 16(2), 2675-2681 (2018-07-18)
The present study examined the differences between gastrointestinal melanoma (GM) and skin melanoma (SM). The clinicopathological characteristics, the expression of melanoma stem cell markers nestin, sex determining region Y-box 2 and ATP-binding cassette sub-family B member 5, and the presence
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）