おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
化学種の反応性
human
テクニック
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CCL19(6363)
詳細
CCL19 (C-C motif chemokine ligand 19) gene is mapped in human chromosome 9p13.3. CCL19 is constantly expressed in secondary lymphoid tissue.
The gene for CCL19 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
免疫原
CCL19 (NP_006265, 11-41)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CCL19.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CCL19.
生物化学的／生理学的作用
CCL19 (C-C motif chemokine ligand 19) is an homeostatic chemokine, involved in adaptive immune system. CCL19 recruits monocytes, macrophages, antigen presenting dendritic cells and naïve T-cells to secondary lymphoid organs by activation of CCR7 (C-C motif chemokine receptor 7). It controls cell migration in inflammation reaction and dysregulated angiogenesis in many types of diseases. CCL19 is upregulated in human atherosclerotic lesions. CCL19 is involved in the development of various inflammatory disorders such as asthma, atherosclerosis and rheumatoid arthritis. CCL19 might also be associated with the pathogenesis of rickettsiae infection.
物理的形状
精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Albert Zlotnik et al.
Genome biology, 7(12), 243-243 (2007-01-05)
The human chemokine superfamily currently includes at least 46 ligands, which bind to 18 functionally signaling G-protein-coupled receptors and two decoy or scavenger receptors. The chemokine ligands probably comprise one of the first completely known molecular superfamilies. The genomic organization
Elisabeth Astrup et al.
BMC infectious diseases, 14, 70-70 (2014-02-11)
Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. Serum levels of CCL19 and CCL21 in patients with R. africae and
Christopher T Veldkamp et al.
Biochemistry, 54(27), 4163-4166 (2015-06-27)
CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by
Hong-Ren Yu et al.
Journal of cellular physiology, 230(9), 2120-2127 (2015-02-07)
Resistin may be an important link between obesity and diabetes. Recent studies have suggested an association between resistin and atherogenic processes. In addition, CCL19 is highly expressed in human atherosclerotic lesions. The interplays among resistin, CCL19, and shear stress in
Yang Qin et al.
BMC musculoskeletal disorders, 15, 316-316 (2014-09-28)
It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases. However, these ligands' precise pathological role in ankylosing spondylitis (AS) has not been elucidated. The objective of this
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）