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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~66 kDa
交差性
human
テクニック
western blot: 1:500-1:2,000
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... DCAF15(90379)
詳細
DCAF15 (DNA damage binding protein1 (DDB1) and cullin4 (CUL4) associated factor 15) gene in human chromosome, is mapped to 19p13.12. DCAF15 lacks protein interaction domain.
DCAF15 protein is a substrate receptor for E3 ligase. This protein is a part of the cullin 4-RING (CRL4)-DCAF15 E3 ubiquitin ligase.
免疫原
synthetic peptide corresponding to amino acids 567-580 of human DCAF15
アプリケーション
Anti-DCAF15 (567-580) antibody produced in rabbit has been used in western blotting.
生物化学的／生理学的作用
DCAF15 (DNA damage binding protein 1 (DDB1) and cullin4 (CUL4) associated factor 15) is the vertebrate ortholog of Saccharomyces pombe chromosome licensing and DNA replication factor 2 (Cdt2) and is required for destruction of Cdt1 during S phase and after DNA damage in human cells.
DCAF15 protein plays a role in RNA splicing and cell apoptosis of various cancer cell lines. This protein is also involved in ubiquitination and degradation of splicing factor RNA binding motif protein 39 (RBM39).
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
Expanding the spectrum of rearrangements involving chromosome 19: A mild phenotype associated with a 19p13.12-p13. 13 deletion
Marangi G, et al.
American Journal of Medical Genetics. Part A, 158(4), 888-893 (2012)
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
Jin J, et al.
Molecular Cell, 23(5), 709-721 (2006)
Zhi Chen et al.
Scientific reports, 7(1), 1175-1175 (2017-04-28)
Cell cycle progression in mammals is strictly controlled by a number of cyclin-dependent kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in cancer cells. Our previous work revealed that Cullin 4B (CUL4B), a critical component
Xiao Dong et al.
Aging, 13(7), 10603-10618 (2021-04-10)
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental program that has been implicated in tumorigenesis and confers metastatic properties upon cancer cells. ZEB1 is a master transcription factor that activates the EMT process in various cancers. ZEB1 is reportedly degraded
Tabitha C Ting et al.
Cell reports, 29(6), 1499-1510 (2019-11-07)
Indisulam and related sulfonamides recruit the splicing factor RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase, resulting in RBM39 ubiquitination and degradation. Here, we used a combination of domain mapping and random mutagenesis to identify domains or residues that are necessary
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