S7826

SMER3

≥98% (HPLC)

• 別名: 9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one
• 実験式（ヒル表記法）: C₁₁H₄N₄O₂
• CAS番号: 67200-34-4
• 分子量: 224.18
• MDL番号: MFCD00451458
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824591
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: yellow
• 溶解性: DMSO: ≥30 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O=C1c2ccccc2-c3nc4nonc4nc13
• InChI: 1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
• InChI Key: SFSSAKVWCKFRHE-UHFFFAOYSA-N

詳細

アプリケーション

SMER3 may be used in cell signaling studies.

生物化学的／生理学的作用

Inhibition of SCF^Met30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.¹

Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable