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About This Item
実験式（ヒル表記法）:
C11H8N2S
CAS番号:
分子量:
200.26
MDL番号:
UNSPSCコード:
12352202
PubChem Substance ID:
NACRES:
NA.25
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品質水準
アッセイ
≥98% (HPLC)
フォーム
solid
溶解性
DMSO: ≥30 mg/mL
保管温度
−20°C
SMILES記法
Nc1nc2c(ccc3ccccc23)s1
InChI
1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)
InChI Key
FECQXVPRUCCUIL-UHFFFAOYSA-N
生物化学的／生理学的作用
SKA31はカリウムチャネルKCa2、KCa3.1のアクチベーターであり、EDHFの反応を増強して血圧を低下させます。
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Irrit. 2
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
S5576-5MG:
S5576-VAR:
S5576-25MG:
S5576-BULK:
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International journal of molecular sciences, 20(17) (2019-08-28)
The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance calcium-activated potassium channels, and to evaluate its influence on endothelium-derived hyperpolarization (EDH)-KCa2.3/KCa3.1 type relaxation in isolated endothelium-intact
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