S3944

SEW2871

≥98% (HPLC), solid

• 別名: 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole
• 実験式（ヒル表記法）: C₂₀H₁₀F₆N₂OS
• CAS番号: 256414-75-2
• 分子量: 440.36
• MDL番号: MFCD00096600
• UNSPSCコード: 12352211
• PubChem Substance ID: 24724607
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 保管条件: protect from light
• 色: white
• mp: 94.5-95.3 °C
• 溶解性: DMSO: ≥10 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
• InChI: 1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
• InChI Key: OYMNPJXKQVTQTR-UHFFFAOYSA-N
• 遺伝子情報: human ... S1PR1(1901) , S1PR2(9294) , S1PR3(1903) , S1PR4(8698) , S1PR5(53637)

詳細

アプリケーション

SEW2871 has been used as a sphingosine-1 phosphate (S1P) receptor agonist to determine the effects of reconstituting plasma apolipoprotein M (ApoM) /S1P on vascular permeability in mice.

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.

生物化学的／生理学的作用

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.

Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist.

特徴および利点

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

包装

Light sensitive.

安全性情報

• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges