おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
lyophilized powder
交差性
rat
テクニック
western blot: 1:200 using rat DRG lysates
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SCN11A(11280)
mouse ... Scn11a(24046)
rat ... Scn11a(29701)
詳細
Sodium Channel NaV1.9 is a threshold channel, that is expressed in dorsal root ganglion neurons , peripheral nociceptive neurons and visceral afferents. It is also called as SNS and NaN. It is encoded by SCN11A (sodium voltage-gated channel subunit 11) and is located on human chromosome 3p22.
免疫原
peptide CNGDLSSLDVAKVKVHND corresponding to residues 1748-1765 of rat Nav1.9. This sequence has 15/18 residues identical in mouse and 14/18 residues identical in human.
生物化学的／生理学的作用
Sodium Channel NaV1.9 participates in pain at the time of inflammation. Downregulation of Nav1.9 is observed in Hirschsprung′s disease.
物理的形状
Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
11 - Combustible Solids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
Biology and management of histologic transformation of indolent lymphoma
Freedman AS, et al.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 314-20 (2005)
Decreased Nav1.9 channel expression in Hirschsprung's disease
O'Donnell AM, et al.
Journal of Pediatric Surgery, 51(9), 1458-1461 (2016)
Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9
Phatarakijnirund V, et al.
Bone, 84, 289-298 (2016)
Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability
Huang J, et al.
The Journal of Clinical Investigation, 127(7), 2805-2814 (2017)
Patrick Delmas et al.
Trends in neurosciences, 26(2), 55-57 (2003-01-22)
Voltage-gated Na(+) channels play key roles in generating and propagating action potentials. Their gating is believed to rely exclusively on changes in membrane potential. However, recent data from Blum, Kafitz and Konnerth provide direct evidence that the opening of Na(v)1.9
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