PZ0345

PF-06700841 tosylate salt

≥98% (HPLC)

• 別名: [(1S)-2,2-Difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.1]oct-8-yl]-methanone tosylate salt
• 実験式（ヒル表記法）: C₁₈H₂₁F₂N₇O · C₇H₈O₃S
• CAS番号: 1883299-62-4
• 分子量: 561.60
• UNSPSCコード: 12352200
• PubChem Substance ID: 329823853
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: room temp
• SMILES記法: FC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6
• InChI Key: FAKGOYNHHHOTEN-VDTKTRGNSA-N

詳細

アプリケーション

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

生物化学的／生理学的作用

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases.

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable