P4124

抗PM/Scl-100 ウサギ宿主抗体

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗EXOSC10抗体, 抗P100抗体, 抗PMSCL2抗体, 抗PMSCL自己抗原, 100-KD抗体, 抗エキソソームコンポーネント10抗体, 抗多発性筋炎/強皮症オーバーラップ症候群関連自己抗原抗体, 抗多発性筋炎/強皮症自己抗原, 100 kDa抗体, 抗多発性筋炎/強皮症自己抗原2抗体, 抗自己抗原PM/Scl 2抗体
• MDL番号: MFCD08705502
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~100 kDa
• 化学種の反応性: human, rat, mouse
• 濃度: ~1.0 mg/mL
• テクニック: indirect immunofluorescence: 1-2 μg/mL using rat NRK and mouse NIH3T3 cells; western blot (chemiluminescent): 1-2 μg/mL using nuclear exracts to HeLa human epithelioid carcinoma cells
• UniProtアクセッション番号: Q01780
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EXOSC10(5394) ; mouse ... Exosc10(50912)

詳細

詳細

PM/SCL-100 (human exosome) is also known as RRP6, EXOSC10 (exosome component 10). It is a heterogeneous autoantibody that is located on human chromosome 1p36. In mouse, EXOSC10 is located on XY body.

免疫原

ヒトPM/Scl-100のアミノ酸残基231~245に相当する合成ペプチド(N末端システイン付加)のKLH結合体。この配列はラット・マウスのPM/Scl-100と同一です。

アプリケーション

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)

生物化学的／生理学的作用

PM/SCL-100 (human exosome) participates in ribosome biogenesis, snoRNA (small nucleolar RNAs)processing, surveillance and degradation of nonfunctional transcripts. It is essential for the production of 40S subunit and to maintain global translation. EXOSC10 participates in mitotic cell division. In mouse, Exosc10 is required for spermatogonial proliferation and early embryogenesis.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable