P0497

抗PMP70抗体 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗70 kDaペルオキシソーム膜タンパク質抗体, 抗ABCD3抗体, 抗PXMP1抗体
• MDL番号: MFCD01865555
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 70 kDa
• 化学種の反応性: human, mouse, rat
• 強化検証: independent; Learn more about Antibody Enhanced Validation
• テクニック: immunoprecipitation (IP): 1-2 μg using RIPA extract (0.5 mg) from human HepG2 cells; indirect immunofluorescence: 4-8 μg/mL using mouse NIH3T3 cells; western blot (chemiluminescent): 0.5-1 μg/mL using whole extracts of rat PC12 cells or rat kidney extract or rat liver extract
• UniProtアクセッション番号: P28288
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ABCD3(5825) ; mouse ... Abcd3(19299) ; rat ... Abcd3(25270)

詳細

詳細

The 70 kDa peroxisomal membrane protein (PMP70) is a major component of peroxisomal membranes. The peroxisome is a multifunctional single-membrane organelle associated with eukaryotic cells. PMP70 belongs to the ATP binding cassette (ABC) transporter superfamily.

免疫原

ラットPMP70のアミノ酸残基644-659に相当する合成ペプチド(N末端システイン付加)のKLH結合体。相当する配列はマウスと同一であり、ヒトと1アミノ酸異なります。

アプリケーション

Anti-PMP70 antibody produced in rabbit has been used in:

• immunocytochemistry
• immunostaining
• immunofluorescence
• western blotting
• immunoprecipitation

生物化学的／生理学的作用

PMP70 participates in the metabolic transport of long and very long fatty acids into peroxisomes. PMP70 interacts and forms a stable complex with the adrenoleukodystrophy protein(ALDP), and also with several other peroxisomal proteins. ATP binding/hydrolysis by PMP70 and ALDL and their phosphorylation are involved in the regulation of fatty acid transport into peroxisomes. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome, an autosomal recessive disorder and is characterized by defects in import mechanism for peroxisomal matrix enzymes.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable