P0081

Monoclonal Anti-PMP22 antibody produced in mouse

~1.0 mg/mL, clone CF1, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-CMT1A, Anti-Charcot-Marie-Tooth neuropathy 1A, Anti-GAS3, Anti-Growth arrest-specific 3, Anti-HNPP, Anti-Peripheral myelin protein 22
• UNSPSCコード: 12352203

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: CF1, monoclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~22 kDa
• 化学種の反応性: human, monkey
• 包装: antibody small pack of 25 μL
• 濃度: ~1.0 mg/mL
• テクニック: immunocytochemistry: suitable; immunohistochemistry: 2.5-5 μg/mL using human spinal cord tissue sections.; indirect ELISA: suitable; western blot: suitable
• アイソタイプ: IgG1
• UniProtアクセッション番号: Q01453
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PMP22(5376)

詳細

詳細

Peripheral myelin protein 22 (PMP22), also known as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein. It is highly expressed in myelin-forming Schwann cells of peripheral nerves. The gene encoding it is localized on human chromosome 17p12–13.

免疫原

peptide corresponding to the second extracellular domain of human PMP22 (amino acids 120-133).

生物化学的／生理学的作用

Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during peripheral nerve development. It also has a role in cell-cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Aberrations or mutations in the PMP22 gene lead to heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML).

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)