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由来生物
human brain
品質水準
アッセイ
≥95% (SDS-PAGE)
フォーム
buffered aqueous solution
比活性
≥10 units/mg protein
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... ENO2(2026)
詳細
Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.
アプリケーション
Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.
生物化学的／生理学的作用
ニュ-ロン特異的エノラ-ゼ(NSE)は全ての神経細胞に発現され、その発現はシナプス機能を獲得していることを示します。急性神経細胞損傷後。神経細胞体ではNSEレベルが高まっています。血清や脳髄液中のNSE高値は、神経損傷および神経細胞死のマ-カ-として用いられています。たいていの神経細胞性腫瘍や神経内分泌腫瘍など、多くの細胞タイプから派生する腫瘍はNSEを発現します。
Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its expression marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE.
Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent manner.
単位の定義
1 unitは、pH 7.4、25°C、1分間で、1.0 μmoleの2-ホスホグリセリン酸をホスホ(エノール)ピルビン酸に変換します。
物理的形状
0.1 M Tris-リン酸(pH 7.0)、0.2 M KCl、5 mM NgSO4の溶液
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
N4773-VAR:
N4773-10UG:
N4773-BULK:
N4773-10UG-PW:
Transplantation of human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia
Li, F., et al.
Molecular Medicine, 6, 625-630 (2012)
Neuron-specific enolase is produced by neuroendocrine tumours
Tapia, F., et al.
Lancet, 317, 808-811 (1981)
T Hattori et al.
Neuroscience research, 21(3), 191-198 (1995-01-01)
We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects
Jo-Heon Kim et al.
Pathology international, 61(12), 762-767 (2011-12-01)
Sinonasal teratocarcinosarcoma (SNTCS) is a very rare tumor developed in the nasal cavity and paranasal sinuses. The rhabdoid phenotype represents an aggressive biological behavior, but the rhabdoid feature has hitherto not been reported in cases of SNTCS. A 46-year-old man
O A Iuneman et al.
Arkhiv patologii, 74(5), 23-26 (2013-01-25)
The paper gives the data of studying the cells belonging to neuroblast progeny in embryonic origin. Differentiation in these cells was studied by immunohistochemical assay using a number of neuronal markers. Expression of S-100, NCAM, and neuron-specific enolase was revealed
資料
Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.
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