MSST0013

SILu^™Prot AMBP Alpha-1 Microglycoprotein human

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, ¹³C and ¹⁵N-labeled

• 別名: Alpha-1-microglobulin, Complex-forming glycoprotein heterogeneous in charge
• UNSPSCコード: 23201100
• NACRES: NA.12

特性

• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in HEK 293 cells
• タグ: His tagged
• アッセイ: ≥98% (SDS-PAGE)
• 形状: lyophilized powder
• 有効性: ≥98% Heavy amino acids incorporation efficiency by MS
• テクニック: mass spectrometry (MS): suitable
• 適合性: suitable for mass spectrometry (standard)
• UniProtアクセッション番号: P02760
• 保管温度: −20°C
• 遺伝子情報: human ... AMBP(259)

詳細

詳細

SILu^™ Prot AMBP is a recombinant, stable isotope-labeled human AMBP which incorporates ^[13C6, ¹⁵N4]-Arginine and [¹³C6, ¹⁵N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of AMBP in mass-spectrometry. SILu^™ Prot AMBP is a monomer of 204 amino acids (including C-terminal polyhistidine and flag tags), with a molecular weight of ~23 kDa.

生物化学的／生理学的作用

AMBP is synthesized by the liver, with approximately half of the circulating protein complexed to IgA. The free form is readily filtered by the glomerulus and reabsorbed by proximal tubule cells. AMBP has been found to be a sensitive biomarker for proximal tubular dysfunction even in the early phase of injury when no histologic damage is observable. In addition, urinary AMBP has been proposed to be a useful marker of tubular dysfunction even in low-gestational-age preterm infants, a population at high risk for AKI (Acute Kidney Injury).

シーケンス

GPVPTPPDNIQVQENFNISRIYGKWYNLAIGSTCPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEKTDTDGKFLYHKSKWNITMESYVVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRETLLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEPEPILIPRVDYKDDDDKGHHHHHHHHGGQ

物理的形状

Supplied as a lyophilized powder containing phosphate buffered saline.

法的情報

SILu is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable