324412

Dynamin Inhibitor III, Phthaladyn-23

• 別名: Dynamin Inhibitor III, Phthaladyn-23, 4-Chloro-2-((2-(3-nitrophenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl)-amino)-benzoic acid
• 実験式（ヒル表記法）: C₂₂H₁₂ClN₃O₇
• 分子量: 465.80
• UNSPSCコード: 12352200
• NACRES: NA.28

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: light yellow to beige
• 溶解性: DMSO: 7 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC₅₀ = 17.4 and 63 µM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K⁺-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC₅₀ = 12.9 µM), while being ineffective at 30 µM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Odell, L.R., et al. 2010. J. Med. Chem.53, 5267.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable