MAK378

Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit

100 fluorometric tests

• 別名: ACE2 Inhibitor Discovery Kit
• UNSPSCコード: 12161503
• NACRES: NA.84

特性

• 使用法: 100 fluorometric tests
• アプリケーション: pharmaceutical
• 検出方法: fluorometric
• 関連疾患: immunological diseases; cardiovascular diseases; genitourinary disorders; pulmonary disorders
• 保管温度: −20°C

詳細

詳細

Angiotensin II converting enzyme (ACE2), a carboxypeptidase, is part of the renin-angiotensin system (RAS) that controls regulation of blood pressure by cleaving the C-terminal dipeptide of Angiotensin II to convert it into Angiotensin 1-7. It also cleaves Angiotensin I to produce Ang 1-9, of unknown function. ACE2 is a receptor of human coronaviruses, such as SARS and HCoV-NL63. It is expressed on the vascular endothelial cells of heart and kidney. The inhibitors of ACE2 could be able to regulate hypertension by changing vascular permeability. Screening for small molecule and peptide inhibitors might also help in finding treatment for coronavirus mediated infection.

特徴および利点

The Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit is compatible with high-throughput handling systems.

適合性

The kit is suitable for Screening/characterizing inhibitors/ligands of ACE2.

原理

The Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE2 activity, it utilizes the ability of an active ACE2 to cleave a synthetic MCA based peptide substrate to release a free fluorophore. The released MCA can be easily quantified using a fluorescence microplate reader. In the presence of an ACE2 specific inhibitor, the enzyme loses its peptidase activity which results in decrease of fluorescence intensity.

その他情報

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安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2