M4937

Anti-Melanocortin-3 Receptor antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 別名: 抗MC3R抗体
• MDL番号: MFCD03455428
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ARR; WB
• クローン: polyclonal
• 化学種の反応性: rat, mouse (predicted)
• citations: 8
• テクニック: microarray: suitable; western blot: 1:2,000 using rat brain homogenate extract

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 40 kDa
• 化学種の反応性: rat, mouse (predicted)
• テクニック: microarray: suitable; western blot: 1:2,000 using rat brain homogenate extract
• UniProtアクセッション番号: P32244
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Mc3r(17201) ; rat ... Mc3r(29310)

詳細

詳細

Melanocortins are regulatory peptides derived from post-translational processing of the larger pro-opiomelanocortin (POMC) precursor. Melanocortin-3 Receptor (MC3-R) is a 360 amino acid containing transmembrane protein that belongs to G-protein coupled receptor family and is expressed mainly in adult central nervous system at high levels in a restricted number of neurons of the hypothalamus and the limbic system.

免疫原

A synthetic peptide corresponding to the N-terminal region of rat melanocortin receptor 3 (amino acids 15-33) coupled to keyhole limpet hemocyanin (KLH). This sequence is highly conserved in mouse MC3-R (89% identity).

アプリケーション

Anti-Melanocortin-3 Receptor antibody produced in rabbit has been used in western blotting and immunocytochemistry.

生物化学的／生理学的作用

Melanocortin-3 (MC3) receptor has a crucial role in facilitating the effects of the melanocortin system on energy homeostasis. The MC3 receptor has been proposed to mediate the actions of MSH, in particular those of α-MSH and γ-MSH peptides. MC3-R is thought to regulate fat stores by a metabolic pathway. MC3-R knockout mice (MC3-R-/-) have increased fat mass, but not high body mass index, are hyperleptinaemic and develop mild hyperinsulinaemia. In contrast to MC3-R, MC4-R primarily controls food intake, suggesting that both MC3 and MC4 receptors may play a complementary role in weight control.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable