M3935

メロキシカム ナトリウム塩 水和物

≥98% (HPLC)

• 別名: 4-ヒドロキシ-2-メチル-N-(5-メチル-2-チアゾリル)-2H-1,2-ベンゾチアジン-3-カルボキサミド1,1-ジオキシド ナトリウム 水和物, UH-AC 62XX ナトリウム塩 水和物, メタカム ナトリウム塩 水和物, モベック ナトリウム塩 水和物
• 実験式（ヒル表記法）: C₁₄H₁₂N₃NaO₄S₂ · xH₂O
• CAS番号: 71125-39-8
• 分子量: 373.38 (anhydrous basis)
• MDL番号: MFCD11046047
• UNSPSCコード: 51111800
• PubChem Substance ID: 24278802
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: light yellow to dark yellow
• 溶解性: DMSO: 5 mg/mL, clear
• オーガナイザー: Boehringer Ingelheim
• 保管温度: room temp
• SMILES記法: O.[Na+].CN1C(C(=O)Nc2ncc(C)s2)=C([O-])c3ccccc3S1(=O)=O
• InChI: 1S/C14H13N3O4S2.Na.H2O/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2;;/h3-7,18H,1-2H3,(H,15,16,19);;1H2/q;+1;/p-1
• InChI Key: IZBZAOZGNNQKPJ-UHFFFAOYSA-M
• 遺伝子情報: human ... PTGS2(5743)

詳細

アプリケーション

Meloxicam sodium salt hydrate has been used:

• as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor
• as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures
• as a reference standard in liquid chromatography electrospray ionisation mass spectrometry (LC-ESI/MS)
• to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein expression in RAW246.7 cells

生物化学的／生理学的作用

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID). It is synthesized from piroxicam with aryl and the pyridyl ring substitution. Meloxicam is a cyclooxygenase-2 (COX-2) inhibitor, it may be useful in treating inflammation and pain. Meloxicam has been shown to stop thymulin-induced increas in concentration of cytokines and Nerve growth factor (NGF) in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro. It promotes apoptosis in hepatocellular carcinoma.

特徴および利点

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319,H335
• 注意書き: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable