M2441

Anti-MAGI-2 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 別名: Anti-ARIP, Anti-S-SCAM
• MDL番号: MFCD03791836
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: IgG fraction of antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 交差性: rat
• テクニック: microarray: suitable; western blot: 1:250 using rat brain extracts
• UniProtアクセッション番号: O88382
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: rat ... Magi2(113970)

詳細

詳細

MAGI-2 is composed of three domains including six PDZ, one guanylate kinase (GK) and two WW domain.

The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.²

MAGI-2 was initially identified in rat, as a protein interacting with N-methyl-D-aspartate receptors (NMDA-R) and neuronal cell adhesion proteins, and was named S-SCAM.⁴Three isoforms of S-SCAM were identified, of 1277, 1113 and 1053 amino acids length, respectively.⁵

免疫原

synthetic peptide corresponding to amino acids 554-571 of MAGI-2/S-SCAM conjugated to KLH.

アプリケーション

Anti-MAGI-2 antibody produced in rabbit has been used in immunoblotting and immunolabeling.

生物化学的／生理学的作用

Membrane associated guanylate kinase inverted-2 (MAGI-2) as well as MAGI-3, was shown to interact with the tumor suppressor PTEN through one of its PDZ domains, apparently acting as a scaffolding protein that could assemble a multi subunit signaling complex. It is known to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable