M1196

抗ムコリピン-2 (C末端) 抗体 ウサギ宿主抗体

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗MCOLN2抗体, 抗MLN2抗体, 抗TRPML2抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~60 kDa
• 化学種の反応性: human
• 包装: antibody small pack of 25 μL
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1 mg/mL
• テクニック: western blot: 0.3-0.6 μg/mL using HEK-293T cells expressing human mucolipin-2
• UniProtアクセッション番号: Q8IZK6
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... MCOLN2(255231)

詳細

詳細

Mucolipin-2 (MLN2) is a member of transient receptor potential (TRP) protein superfamily. It consists of gated, tetrameric cation channels. MLN2 has a conserved structure of six transmembrane helices with differing cytoplasmic oriented N- and C-terminal domains. It is localized to late endosomes and lysosomes..

特異性

凝集・分解により、120 kDa・35 kDa付近に別のバンドが認められる場合があります。

免疫原

ヒトムコリピン-2のアミノ酸534~549に相当する合成ペプチド。 この配列はラット (73%同一) およびマウス (66%相同) ムコリピン-2との相同性は低いです。

アプリケーション

Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

生物化学的／生理学的作用

Mucolipin-2 (MLN2) plays an important role in lysosome maturation, lysosome fission, late endosome-lysosome fusion, autophagosome-lysosome fusion, lysosome expulsion and iron release. It stimulates autophagy proliferation via transcription factor EB (TFEB) activation. MLN2 is involved in B‐lymphocyte development.

物理的形状

0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)