M0800
Anti-p38 MAP Kinase antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
別名:
Anti-ERK, Anti-ERK-2, Anti-ERK2, Anti-ERT1, Anti-MAPK2, Anti-NS13, Anti-P42MAPK, Anti-PRKM1, Anti-PRKM2, Anti-p38, Anti-p40, Anti-p41, Anti-p41mapk, Anti-p42-MAPK
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About This Item
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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 40 kDa
化学種の反応性
mouse, rat
テクニック
microarray: suitable
western blot: 1:10,000 using NIH3T3 mouse fibroblast lysate and rat brain extract
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... MAPK1(5594)
mouse ... Mapk1(26413)
rat ... Mapk1(116590)
詳細
P38 MAPK is a mitogen-activated protein kinase (MAPK) that belongs to serine/threonine protein kinases family and is activated in response to stress signals like- osmolarity changes, UV-irradiation, heat shock,cytokines and lipopolysaccharides (LPS). It mainly expresses in brain, muscle, thymus, spleen, heart, lung, kidney and fibroblasts.
特異性
Rabbit anti-p38 MAP Kinase antibody reacts specifically with p38 MAP kinase from mouse and rat.
免疫原
免疫原はマウスp38 MAPキナーゼのC末端に由来する合成ペプチド(アミノ酸343-360, N末端リジン付加:K-DEVISFVPPPLDQEEMES)のKLH結合体です。この配列はヒト、ラットp38 MAPキナーゼで高度に保存されています。
アプリケーション
Anti-p38 MAP Kinase antibody has been used in western blotting (diluted 1:1000) using using NIH 3T3 mouse fibroblasts cell lysate and rat brain extract. It has also been used in microarray.
生物化学的／生理学的作用
Mitogen-activated protein kinases (MAP kinases, MAPKs) are a family of protein kinases which are considered to play a crucial role in signal transduction pathways in mammalian cells by leading mitogenic signals to their intracellular targets. MAP kinases regulate several cellular processes, such as proliferation, differentiation, response to stress and oncogenesis. p38 MAPK is activated in response to stress signals like- osmolarity changes, ultravoilet-irradiation, heat shock, cytokines and lipopolysaccharides (LPS). It is required for phosphorylation of MAPK-activated protein kinase 2 (MAPKAPK-2). Anti-p38 MAP Kinase antibody can be used to study the differential tissue expression, specific activation requirements and intracellular localization of MAP kinase isoforms in normal and neoplastic tissues.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
M0800-BULK:
M0800-.2ML:
M0800-VAR:
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