L9761

[D-Trp⁶]-LH-RH

≥97% (HPLC), powder

• 別名: [D-Trp⁶]-Luteinizing hormone releasing hormone
• 実験式（ヒル表記法）: C₆₄H₈₂N₁₈O₁₃
• CAS番号: 57773-63-4
• 分子量: 1311.45
• MDL番号: MFCD00167541
• UNSPSCコード: 12352209
• PubChem Substance ID: 329817674
• NACRES: NA.32

特性

• 品質水準: 200
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• UniProtアクセッション番号: P01148; P30968
• 保管温度: −20°C
• SMILES記法: CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](Cc6c[nH]cn6)NC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N8CCC[C@H]8C(=O)NCC(N)=O
• InChI: 1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1
• InChI Key: VXKHXGOKWPXYNA-PGBVPBMZSA-N
• 遺伝子情報: human ... GNRH1(2796) , GNRHR(2798)

詳細

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-NH2

アプリケーション

[D-Trp6]-LH-RH (luteinizing hormone releasing hormone) has been used to study whether the (M^. – X) region in electron capture dissociation provides information on amino acid composition of polypeptides. It is also used to study the effect of LH-RH on the production of progesterone (P), estradiol (E2) or human chorionic gonadotropin (hCG) by JEG-3 choriocarcinoma cells.

生物化学的／生理学的作用

Potent LH-RH agonist with enhanced biological activity due to its slower rate of degradation. Like [D-Lys⁶]-LH-RH, the D-Trp⁶ analog has been shown to be effective against cancers expressing the LH-RH receptor. However, unlike the D-Lys⁶ analog, it is generally used in the unconjugated form.

包装

底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H360
• 注意書き: P201 - P308 + P313
• 危険有害性の分類: Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges