おすすめの製品
由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
9824, monoclonal
フォーム
lyophilized powder
化学種の反応性
human
テクニック
capture ELISA: 2-4 μg/mL
immunohistochemistry: 25 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... LIF(3976)
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免疫原
purified, E. coli-derived recombinant human leukemia inhibitory factor.
生物化学的／生理学的作用
Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL-6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-c Fos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic cell differentiation.
物理的形状
凍結乾燥品(PBS溶液, 5%トレハロース含有, 0.2 μmフィルター滅菌済み)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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関連製品
製品番号
詳細
価格
保管分類コード
13 - Non Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
L0669-500UG:
L0669-BULK:
L0669-VAR:
L0669-500UG-PW:
最新バージョンのいずれかを選択してください：
Xi Cheng et al.
Reproductive biology and endocrinology : RB&E, 15(1), 42-42 (2017-06-05)
A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect
Marie-Emmanuelle Mathieu et al.
Stem cell reviews, 8(1), 1-15 (2011-05-04)
LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation
D J Hilton
Trends in biochemical sciences, 17(2), 72-76 (1992-02-01)
Leukaemia inhibitory factor (LIF) is one of a growing number of cytokines that cannot be readily categorized according to its functions. Rather, these pleiotropic hormones have diverse and often overlapping effects on a multitude of cell types: for example, LIF
S M Metcalfe
Genes and immunity, 12(3), 157-168 (2011-03-04)
At the heart of lineage commitment within the adaptive immune response is the intrinsic genetic plasticity of the naive peripheral T lymphocyte (T cell). Primary activation by presentation of cognate antigen is coupled to rapid T-cell cycling and progressive epigenetic
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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