K3269

抗キンドリン-2抗体 ウサギ宿主抗体

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗FERMT2抗体, 抗KIND2抗体, 抗MIG2抗体, 抗PLEKHC1抗体, 抗UNC112B抗体, 抗UNC112抗体, 抗フェルミチンファミリーホモログ2抗体, 抗プレクストリン相同ドメイン含有ファミリーC, メンバー1抗体, 抗マイトジェン誘導性遺伝子2タンパク質抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~72 kDa
• 化学種の反応性: mouse, rat, canine, human
• 濃度: ~1.0 mg/mL
• テクニック: indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells; western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells
• UniProtアクセッション番号: Q96AC1
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FERMT2(10979) ; mouse ... Fermt2(218952) ; rat ... Fermt2(289992)

詳細

詳細

Anti-kindlin-2 recognizes human, mouse, rat and canine kindlin-2. Kindlin-2, also known as fermitin family member 2 (FERMT2) or pleckstrin homology domain-containing family C member 1 (PLEKHC1), is encoded by the gene mapped to human chromosome 14q22.1. Kindlin-2 is a member of the kindlin protein family and has a ubiquitous expression pattern.

アプリケーション

Anti-kindlin-2 antibody produced in rabbit has been used in western blotting.

生物化学的／生理学的作用

Kindlin-2 acts as a focal adhesion protein and controls breast cancer progression by promoting genome instability. Kindlin-2, as an integrin-interacting protein, plays a vital role in integrin activation and integrin-mediated cell-extracellular matrix (ECM) interaction. Kindlin-2 expression is associated with poor prognosis of patients with hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinomas (PDACs). Therefore, kindlin-2 can be considered as a potential biomarker for patients with HCC and PDACs.

物理的形状

0.01M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

保管および安定性

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

その他情報

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable