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About This Item
実験式（ヒル表記法）:
C20H30O2
CAS番号:
分子量:
302.45
MDL番号:
UNSPSCコード:
12352106
PubChem Substance ID:
NACRES:
NA.77
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品質水準
アッセイ
≥98% (GC)
フォーム
powder
色
white
溶解性
DMSO: 25 mg/mL
保管温度
−20°C
SMILES記法
[H][C@]12CC[C@@](C)(CC1=CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O)C=C
InChI
1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1
InChI Key
MXYATHGRPJZBNA-KRFUXDQASA-N
詳細
Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.
生物化学的／生理学的作用
Potent opener of large conductance calcium activated K+ (BK) channels.
特徴および利点
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
I6783-5MG:
I6783-25MG:
I6783-VAR:
I6783-BULK:
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Neil C Henney et al.
American journal of physiology. Cell physiology, 297(6), C1397-C1408 (2009-09-25)
The pharmacology of the large-conductance K(+) (BK) channel in human osteoblasts is not well defined, and its role in bone is speculative. Here we assess BK channel properties in MG63 cells and primary human osteoblasts and determine whether pharmacological modulation
Eileen Smith et al.
Phytotherapy research : PTR, 19(6), 538-542 (2005-08-23)
The diterpene isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were
Yuji Imaizumi et al.
Molecular pharmacology, 62(4), 836-846 (2002-09-19)
Effects of pimaric acid (PiMA) and eight closely related compounds on large-conductance K(+) (BK) channels were examined using human embryonic kidney (HEK) 293 cells, in which either the alpha subunit of BK channel (HEKBKalpha) or both alpha and beta1 (HEKBKalphabeta1)
Dawn E Hall et al.
Plant physiology, 161(2), 600-616 (2013-02-02)
Diterpene resin acids (DRAs) are major components of pine (Pinus spp.) oleoresin. They play critical roles in conifer defense against insects and pathogens and as a renewable resource for industrial bioproducts. The core structures of DRAs are formed in secondary
Isolation and characterization of isopimaric acid-degrading bacteria from a sequencing batch reactor.
Wilson AE, et al.
Applied and Environmental Microbiology, 62(9), 3146-3151 (1996)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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