I4026

Interleukin-17 from mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 別名: CTLA-8, IL-17
• MDL番号: MFCD01635117
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: mouse
• 品質水準: 200
• リコンビナント: expressed in E. coli
• アッセイ: ≥97% (SDS-PAGE)
• フォーム: lyophilized powder
• 分子量: 16.5 kDa
• 包装: pkg of 25 μg
• テクニック: cell culture | mammalian: suitable
• 不純物: endotoxin, tested
• UniProtアクセッション番号: Q62386
• 保管温度: −20°C
• 遺伝子情報: mouse ... Il17a(16171)

詳細

生物化学的／生理学的作用

当初はCTLA-8と言われたT細胞が発現するポリペプチドであり、造血系の調節に関与すると考えられています。繊維芽細胞においてIL-6, IL-8, G-CSFの産生を誘導することが確認されており、これらのサイトカインはすべて造血作用を示しています。

IL-17 (interleukin-17) participates in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways and CCAAT/enhancer-binding protein family of transcription factors, thereby regulating pro-inflammatory and antimicrobial genes. In rheumatoid arthritis, IL-17 is responsible for the inflammation as well as destruction of joints.

Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

物理的形状

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg of bovine serum albumin.

アナリシスノート

The biological activity of mouse IL-17 is measured by its ability to induce IL-6 production using NIH/3T3 cells.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)