コンテンツへスキップ
Merck

HPA036087

Sigma-Aldrich

Anti-SLC35A2 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

別名:

抗UGT1抗体

ログイン組織・契約価格を表示する


About This Item

UNSPSCコード:
12352203
Human Protein Atlas Number:

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

製品種目

Prestige Antibodies® Powered by Atlas Antibodies

形状

buffered aqueous glycerol solution

化学種の反応性

human

テクニック

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50

免疫原配列

RGAAKAIASASASASGPCVHQQPPGQPPPPQLSSHRGDLITEPFLPKLLTKVKGS

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... SLC35A2(7355)

関連するカテゴリー

詳細

Solute carrier family 35 member A2 (SLC35A2) gene is mapped to human chromosome Xp11.23. This gene codes for Uridine diphosphate (UDP)-galactose transporter (UGT). UGT belongs to the family of nucleotide sugar transporters (NSTs). UGT1 and UGT2 are the two alternative splicing variants of UGT.

免疫原

溶質キャリアファミリー35(UDP-ガラクトース輸送体)メンバーA2のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SLC35A2 antibody produced in rabbit has been used in western blotting.

生物化学的/生理学的作用

Uridine diphosphate (UDP)-galactose transporter (UGT) facilitates the transport of UDP-galactose to the Golgi apparatus. Short N-terminal region of UGT is responsible for galactosylation of N-glycans. Mutation in the gene is associated with the development of congenital disorders of glycosylation (CDG) and early-onset epileptic encephalopathy and developmental delay.

特徴および利点

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST78271

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

適切な製品が見つかりませんか。  

製品選択ツール.をお試しください

保管分類コード

10 - Combustible liquids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

A case of early onset epileptic encephalopathy with de novo mutation in SLC35A2: clinical features and treatment for epilepsy
Kimizu T, et al.
Brain & Development, 39(3), 256-260 (2017)
A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface
Stewart SE, et al.
Journal of Cell Science, 130(19), 3234-3247 (2017)
SLC35A2-related congenital disorder of glycosylation: Defining the phenotype
Yates TM, et al.
European Journal of Paediatric Neurology, 22(6), 1095-1102 (2018)
Short N-terminal region of UDP-galactose transporter (SLC35A2) is crucial for galactosylation of N-glycans
Sosicka P, et al.
Biochemical and Biophysical Research Communications, 454(4), 486-492 (2014)
Chien-Liang Liu et al.
In vivo (Athens, Greece), 37(1), 262-269 (2023-01-03)
A recent study suggested that solute carrier family 35 member A2 (SLC35A2) is related to poor prognosis in patients with breast cancer. SLC35A2 transports uridine diphosphate-galactose from the cytosol to the lumen of the endoplasmic reticulum and Golgi. Immunohistochemical expression

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

製品に関するお問い合わせはこちら(テクニカルサービス)