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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
製品種目
Prestige Antibodies® Powered by Atlas Antibodies
形状
buffered aqueous glycerol solution
化学種の反応性
human, mouse, rat
テクニック
immunoblotting: 1:100-1:250
immunohistochemistry: 1:200-1:500
免疫原配列
AGGQHLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLH
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SP6(80320)
詳細
SP6 (sp6 transcription factor), also called as KLF14 (kruppel-like factor 14) or Epfn (epiprofin) belongs to SP/KLF (kruppel-like factor) transcription factor family. The protein is encoded by maternally inherited intronless gene, mapped to human chromosome 17q21.3-q22.
KLF14 transcription factor is predominantly expressed in fetal tissues and placenta than in adult tissues. The encoded protein consists of three C2H2-type zinc-fingers attached to each other by kruppel-links at the end of the carboxy-terminal domain and transactivation/suppressor domain at the end of the N-terminal domain.
KLF14 transcription factor is predominantly expressed in fetal tissues and placenta than in adult tissues. The encoded protein consists of three C2H2-type zinc-fingers attached to each other by kruppel-links at the end of the carboxy-terminal domain and transactivation/suppressor domain at the end of the N-terminal domain.
免疫原
Sp6 transcription factor recombinant protein epitope signature tag (PrEST)
アプリケーション
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生物化学的／生理学的作用
SP6 (sp6 transcription factor) might be involved in regulation of transcription process. In mice, SP6 or Epfn (Epiprofin) is involved in epidermal development.
TGF (transforming growth factor)-β treatment upregulates SP6 or KLF14 (Kruppel-like factor 14), which is a vital non-smad protein that potentially represses the transforming growth factor-β receptor II (TGF-βRII). SP6 aids in tooth development by regulating the epithelial cell fate and tooth number.
TGF (transforming growth factor)-β treatment upregulates SP6 or KLF14 (Kruppel-like factor 14), which is a vital non-smad protein that potentially represses the transforming growth factor-β receptor II (TGF-βRII). SP6 aids in tooth development by regulating the epithelial cell fate and tooth number.
特徴および利点
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
関連事項
Corresponding Antigen APREST75965
物理的形状
PBS溶液（pH 7.2、40％グリセロール、0.02％ アジ化ナトリウム含有）
法的情報
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
HPA024516-25UL:
HPA024516-100UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
S Scohy et al.
Genomics, 70(1), 93-101 (2000-11-23)
Using the sequence of the SP1 zinc-finger DNA-binding domain as a probe to screen a mouse EST database, we identified two novel members of the SP/XKLF transcription factor family, KLF13 and KLF14. The mouse Klf13 cDNA (1310 bp in length)
Takashi Nakamura et al.
The Journal of biological chemistry, 283(8), 4825-4833 (2007-12-25)
In tooth morphogenesis, the dental epithelium and mesenchyme interact reciprocally for growth and differentiation to form the proper number and shapes of teeth. We previously identified epiprofin (Epfn), a gene preferentially expressed in dental epithelia, differentiated ameloblasts, and certain ectodermal
C R Gonzalez et al.
Cytokine, 61(2), 670-675 (2013-01-16)
Transforming growth factor β1 (TGF-β1) is a pleiotropic cytokine that modulates cell homeostasis. In Leydig cells, TGF-β1 exerts stimulatory and inhibitory effect depending on the type I receptor involved in the signaling pathway. The aim of the present work was
Layla Parker-Katiraee et al.
PLoS genetics, 3(5), e65-e65 (2007-05-08)
Imprinted genes are expressed in a parent-of-origin manner and are located in clusters throughout the genome. Aberrations in the expression of imprinted genes on human Chromosome 7 have been suggested to play a role in the etiologies of Russell-Silver Syndrome
Takashi Nakamura et al.
Journal of cell science, 127(Pt 24), 5261-5272 (2014-10-26)
The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number of molecules have been identified as regulators of this process, including p63
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