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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
製品種目
Prestige Antibodies® Powered by Atlas Antibodies
形状
buffered aqueous glycerol solution
化学種の反応性
mouse, human, rat
強化検証
RNAi knockdown
Learn more about Antibody Enhanced Validation
テクニック
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200
免疫原配列
SFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIR
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... FYN(2534)
詳細
FYN (proto-oncogene, Src family tyrosine kinase) is located in human chromosome 6q21.
Fyn is a non-receptor type tyrosine kinase also called as tau kinase, which belongs to the Src family. It has two isoforms, FynB and FynT, expressed in brain and T-lymphocytes, respectively. The Fyn protein consist of Src homology domain 2 (SH2) and Src homology domain 3 (SH3) at its amino terminal ends.
免疫原
FYN proto-oncogene, Src family tyrosine kinase
アプリケーション
Prestige抗体®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。
Anti-FYN antibody has been used in western blotting and sodium dodecyl sulphate-polyacrylamide gel electrophoresis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生物化学的／生理学的作用
FynT, an isoform of tyrosine-protein kinase Fyn, regulates neurofibrillary degeneration and reactive astrogliosis in Alzheimer′s disease (AD). The tyrosine kinase Fyn plays a vital role in acute transplant rejection, by phosphorylating tyrosine residues on key targets that take part in early T-cell signal transduction, which is a crucial process for acute transplant rejection. p59fyn (T) controls OKT3 promoted calcium ion transport in Jurkat T cells . Fyn facilitates the phosphorylation of Vav, a guanine nucleotide exchange factor for Rho-like small GTPases, and plays a crucial role in TCR-mediated actin polymerization. The Fyn protein associates with large myelin-associated glycoprotein (MAG) and plays a major role in myelinogenesis.
特徴および利点
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
関連事項
Corresponding Antigen APREST78892
物理的形状
PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。
法的情報
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
HPA023887-100UL:
HPA023887-25UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease.
Lau DH
Acta Neuropathologica Communications, 4(1):49 (2016)
T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.
Huang J
Proceedings of the National Academy of Sciences of the USA, 97(20), 10923-10929 (2000)
Dawn H W Lau et al.
Acta neuropathologica communications, 4(1), 49-49 (2016-05-20)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles comprised of β-amyloid and tau protein, respectively. In AD, tau becomes abnormally phosphorylated and aggregates to form intracellular deposits. However, the mechanisms
Role of Fyn-mediated NMDA receptor function in prediabetic neuropathy in mice.
Suo M, et al.
Journal of Neurophysiology, 116(2), 448-455 (2016)
Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.
Weil R
Journal of Virology, 73(5), 3709-3717 (1999)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）