HPA010725

抗C1orf43抗体 ウサギ宿主抗体

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: 抗C1orf43(性質不明タンパク質)抗体 ウサギ宿主抗体, 抗C型肝炎ウイルスNS5Aトランス活性化タンパク質4抗体 ウサギ宿主抗体, 抗HCV NS5Aトランス活性化タンパク質4抗体 ウサギ宿主抗体, 抗NICE-3タンパク質抗体 ウサギ宿主抗体, 抗S863-3抗体 ウサギ宿主抗体
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA010725
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• 形状: buffered aqueous glycerol solution
• 化学種の反応性: human
• テクニック: immunohistochemistry: 1:200- 1:500
• 免疫原配列: AMKSRRGPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLYRMKALDAIRTS
• UniProtアクセッション番号: Q9BWL3
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... C1orf43(25912)

詳細

詳細

C1orf43 (chromosome 1 open reading frame 43) belongs to epidermal differentiation complex (EDC) family of genes. It is mapped to human chromosome 1q21, and has three cDNA variants owing to alternative splicing. It might have the structural characteristics of N-4 cytosine-specific DNA methylases, and is expressed in multiple tissues. It is also found in CD34⁺ hematopoietic stem cells (HSPCs). C1orf43 gene shares no homology with any of the existing EDC families.

免疫原

C1orf43(性質不明タンパク質)のPrEST (protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

EDC (epidermal differentiation complex) family of genes is responsible for the normal maturation of epidermis and is therefore, linked with skin diseases. EDC is also associated with carcinogenesis, and the expression of C1orf43 is found to be up-regulated in human hepatocellular carcinoma (HCC). Increased expression of this gene in Focus and WRL-68 HCC cell lines leads to cell proliferation and colony formation. Studies also suggest that this protein is induced by NS5A (non-structural protein 5A) present in hepatitis C virus (HCV). Therefore, C1orf43 might lead to HCV-related HCC. Fibrolamellar carcinomas (FLC), a rare form of HCC, also shows increased levels of C1orf43 expression. Hence, C1orf43 might be an oncogene for HCC. The up-regulation of this gene can also act as a marker for poor prognosis, and determination of malignance in breast cancer.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST72033

物理的形状

PBS溶液 (pH 7.2, 40%グリセロ-ルおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)