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由来生物
chicken
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
human
メーカー／製品名
Genway 15-288-21011
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ADRB2(154)
詳細
β-2 Adrenergic Receptor is a member of the seven-transmembrane-domain receptor family. The ADRB2 gene is mapped on the human chromosome at 5q32. β-2 Adrenergic Receptor is a seven-transmembrane protein that consists of α helices. The N-terminal is extracellular whereas the C-terminal is intracellular.
免疫原
Immunogen Sequence: GI # 4501969, sequence 335-408
Recombinant adrenergic, β-2-, receptor, surface
アプリケーション
Anti-β-2 Adrenergic Receptor antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生物化学的／生理学的作用
The β-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is present within a cell membrane. It reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It may be a risk factor for chronic pain and its polymorphisms may influence labor pain. It contains a common non-synonymous single nucleotide polymorphism. Epinephrine activates ADRB2 impairing keratinocyte migration. β2-adrenoceptor pathway is essential for cardiovascular regulation.
物理的形状
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
GW21011-BULK:
GW21011-50UG:
GW21011-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
U H Frey et al.
British journal of anaesthesia, 112(3), 477-484 (2013-12-25)
While the β2-adrenoceptor pathway is essential for cardiovascular regulation, the impact of ADRB2 gene variations on circulatory responses is unclear, possibly due to neural compensatory mechanisms. We tested the hypotheses that (i) sympathetic block by thoracic epidural anaesthesia (TEA) unmasks
Dennis W McGraw et al.
Proceedings of the American Thoracic Society, 2(4), 292-296 (2005-11-04)
It is now clear that the beta2-adrenergic receptor continuously oscillates between various conformations in the basal state, and that agonists act to stabilize one or more conformations. It is conceivable that synthetic agonists might be engineered to preferentially confine the
R A Hall et al.
Nature, 392(6676), 626-630 (1998-04-29)
Stimulation of beta2-adrenergic receptors on the cell surface by adrenaline or noradrenaline leads to alterations in the metabolism, excitability, differentiation and growth of many cell types. These effects have traditionally been thought to be mediated exclusively by receptor activation of
Victor E Ortega et al.
The Lancet. Respiratory medicine, 2(3), 204-213 (2014-03-14)
Severe adverse life-threatening events associated with longacting β agonist (LABA) use have caused the US Food and Drug Administration (FDA) to review the safety of these drugs, resulting in a boxed warning and a mandatory safety study in 46 800 patients
Abdullah S Terkawi et al.
Anesthesiology, 121(1), 140-148 (2014-04-10)
Variability in labor pain has been associated with demographic, clinical, and psychological factors. Polymorphisms of the β2-adrenergic receptor gene (ADRB2) influence sensitivity to experimental pain in humans and are a risk factor for chronic pain. The authors hypothesized that polymorphisms
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