GW10817F

Anti-TAT antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-Protein Tat, Anti-Transactivating regulatory protein
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: chicken
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• メーカー／製品名: Genway 15-288-10817F
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_057853.1
• UniProtアクセッション番号: P04608
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... tat(155871)

詳細

免疫原

Immunogen Sequence: GI # 9629358, sequence 1-86

Recombinant tat (human immunodeficiency virus 1)

アプリケーション

Anti-TAT antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200.

生物化学的／生理学的作用

TAT (Transactivating regulatory protein) is a trans-activator of human immunodeficiency virus-1 (HIV-1) gene expression and is important for virus replication. It binds to the bulge loop RNA element called TAR, but can also associate with cellular transcription factors. Cyclin T binds with TAT and thereby enhances the affinity of TAT-TAR RNA interaction. Protein arginine methyltransferase-6 (PRMT6) is responsible for methylation of TAT and negatively affects the association between TAT and cyclin T. TAT is involved in the activation of nuclear factor κB (NFκB), a master regulator of pro-inflammatory genes. TAT binds with α5β1 and αvβ3 integrins, and causes vascular cell migration and invasion. At the neural plasma membrane, TAT induces formation of a complex involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), N-methyl-d-aspartic acid (NMDA) receptors and neuronal nitric oxide synthase (nNOS). This complex is responsible for apoptosis in neurons and astrocytes, causing neurologic dysfunction in AIDS patients.

物理的形状

Solution in phosphate buffered saline containing 0.02% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)