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包装
pack of 2500 U
メーカー／製品名
Cytiva E70073Z
輸送温度
dry ice
保管温度
−20°C
詳細
Exonuclease I.
The EXO1 (exonuclease I) gene is mapped to human chromosome 1q43 and codes for a 5′→3′ exonuclease of 846 amino acids. It belongs to the 5′-nuclease superfamily.
アプリケーション
Acts specifically on single-stranded DNA degrading it processively in the 3′- to 5′-direction, producing 5′-mononucleotides.
生物化学的／生理学的作用
Exonuclease I (EXO1) maintains genomic stability by participating in DNA mismatch repair system, DNA recombination, DNA replication and DNA double-stranded break repair in eukaryotes. It also modulates meiosis, immunoglobulin maturation, and micro-mediated end-joining. It functions on DNA with blunt, nicked, gapped and 3′-overhangs. It also possesses endonuclease action and removes 5′-single-stranded flaps that protrudes from a double stranded DNA. Mutation in EXO1 gene results in increased susceptibility to develop cancer.
特徴および利点
- Eliminating residual single-stranded DNA containing a 3′-terminus.
- Measuring endonucleolytic cleavage of covalently closed circular (ccc) ssDNA.
- Measuring DNA helicase activity.
保管および安定性
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
アナリシスノート
この製品の分析証明書は、www.cytiva.com.
保管分類コード
12 - Non Combustible Liquids
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Human Exonuclease 1 Threads 5?-Flap Substrates through Its Helical Arch.
Shaw S J, et al.
Biochemistry, 56(29), 3704-3707 (2017)
Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma.
Tan S, et al.
Oncotarget, 7(52), 87180-87180 (2016)
Exonuclease 1 and its versatile roles in DNA repair.
Keijzers G, et al.
Critical Reviews in Biochemistry and Molecular Biology, 51(6), 440-451 (2016)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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