おすすめの製品
由来生物
rabbit
結合体
unconjugated
抗体製品の状態
whole antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
含みます
15 mM sodium azide
化学種の反応性
human
テクニック
dot blot: 1:50 using galactocerebroside I and II
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... GALC(2581)
詳細
Galactocerebroside is the major galactosphingolipid of myelin. It is expressed in the CNS in cell membranes of oligodendrocytes. It is also expressed in Schwann cells in peripheral nerves.
This product is a pooled delipidized antiserum produced in rabbits by repeated injections of a mixture of galactocerebrosides I and II conjugated to keyhole limpet hemocyanin.
特異性
本抗体は培養細胞のオリゴデンドログリアを特定します。培養中のオリゴデンドログリア膜シ-トの組織化の変化を研究する際に利用することができます。特異性は、抗原としてガラクトセレブロシドを使用したドットブロッティングによって判定しています。
免疫原
ガラクトセレブロシド(GalC)IおよびIIのKLH結合体
アプリケーション
Anti-Galactocerebroside antibody produced in rabbit has been used:
- for dot-blot immunoassay and western blot analysis of mouse brain homogenates
- as a primary antibody at a working dilution of 1:50 for immunostaining of muscle tissue of Rana pipiens frogs
- as a primary antibody at a working dilution of 1:500 in immunofluorescence and immunohistochemistry using primary human astroglia
生物化学的／生理学的作用
Galactocerebroside is the major galactosphingolipid of myelin. It is expressed in the CNS in cell membranes of oligodendrocytes. It is also expressed in Schwann cells in peripheral nerves. Galactocerebroside is found in serum and cerebral spinal fluid of patients with demyelinating diseases like multiple sclerosis.
Galactocerebroside was shown to play an important role in the processes of normal development and myelination and is known to be an early marker of oligodendrocyte development.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
G9152-BULK:
G9152-.2ML:
G9152-.5ML:
G9152-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
J Georgiou et al.
Glia, 27(2), 101-109 (1999-07-27)
Perisynaptic Schwann cells (PSCs) envelop axonal terminals and are physiologically distinct from the nearby myelinating Schwann cells (MSCs), which surround the same innervating motor axons. PSCs have special functions at the neuromuscular synapse, where they detect and can modulate neurotransmitter
B Zalc et al.
Brain research, 211(2), 341-354 (1981-05-04)
We have used purified antibodies against galactosylceramide (galCb) and sulfogalactosylceramide (sulf) to study the topographical distribution of these two lipid haptens in the brain of the 30-day-old mouse. This study has been conducted, using the indirect immunofluorescence method, on cerebellum
Lead alters the developmental profile of the galactolipid metabolic enzymes in cultured oligodendrocyte lineage cells
Deng W and Poretz RD
Neurotoxicology, 22(4), 429-437 (2001)
J W Prineas et al.
Laboratory investigation; a journal of technical methods and pathology, 61(5), 489-503 (1989-11-01)
Fresh lesions in the brain and spinal cord of patients with multiple sclerosis who died shortly after the onset of symptoms were examined immunocytochemically for myelin and oligodendrocyte antigens that are known to be sequentially expressed during normal development. Cells
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture.
M C Raff et al.
Nature, 274(5673), 813-816 (1978-08-24)
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