G5044

GR 32191B

≥98% (HPLC), solid

• 別名: (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-ビフェニル]-4-イルメトキシ)-3-ヒドロキシ-2-(1-ピペリジニル)シクロペンチル]-4-ヘプテン酸 塩酸塩
• 実験式（ヒル表記法）: C₃₀H₄₀NO₄Cl
• CAS番号: 87248-13-3
• 分子量: 514.10
• MDL番号: MFCD04113055
• UNSPSCコード: 12352200
• PubChem Substance ID: 329799744
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• 色: off-white
• mp: 127-128 °C
• 溶解性: H₂O: ~16 mg/mL
• オーガナイザー: GlaxoSmithKline
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: Cl.O[C@H]1C[C@H](OCc2ccc(cc2)-c3ccccc3)[C@H](CC\C=C/CCC(O)=O)[C@H]1N4CCCCC4
• InChI: 1S/C30H39NO4.ClH/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31;/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34);1H/b2-1-;/t26-,27-,28-,30+;/m0./s1
• InChI Key: ZYOBZRTZRQKKNC-UGNABIHOSA-N

詳細

生物化学的／生理学的作用

Selective TP prostanoid receptor antagonist. Inhibits U-46619-induced contraction of guinea pig trachea with IC₅₀=1.8 nM.

特徴および利点

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法的情報

Manufactured and sold under agreement from Glaxo­Smith­Kline

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)