G0668

GW2974

≥98% (HPLC), solid

• 別名: N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine
• 実験式（ヒル表記法）: C₂₃H₂₁N₇
• CAS番号: 202272-68-2
• 分子量: 395.46
• MDL番号: MFCD04974495
• UNSPSCコード: 51111800
• PubChem Substance ID: 24278451
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 色: yellow
• 溶解性: DMSO: ≥20 mg/mL
• オーガナイザー: GlaxoSmithKline
• SMILES記法: CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1
• InChI: 1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)
• InChI Key: DYYZXRCFCVDSKD-UHFFFAOYSA-N
• 遺伝子情報: human ... EGFR(1956) , ERBB2(2064)

詳細

生物化学的／生理学的作用

レセプター型チロシンキナーゼEGFRとErbB-2(IC₅₀ = 0.016 μM)に対する強力かつ選択的なデュアルインヒビターです。

特徴および利点

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法的情報

Sold for research purposes under agreement from Glaxo­Smith­Kline

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)