F1678

R-(−)-Fluoxetine hydrochloride

>98% (HPLC), solid

• 別名: (R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride
• 実験式（ヒル表記法）: C₁₇H₁₈NOF₃ · HCl
• CAS番号: 114247-09-5
• 分子量: 345.79
• MDL番号: MFCD04040065
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278433
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: >98% (HPLC)
• 形状: solid
• 保管条件: desiccated
• 色: white
• 溶解性: H₂O: soluble >10 mg/mL
• オーガナイザー: Eli Lilly
• SMILES記法: Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1
• InChI Key: GIYXAJPCNFJEHY-PKLMIRHRSA-N
• 遺伝子情報: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

詳細

アプリケーション

R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:

• to study its effects on the embryoid body (EB) morphogenesis
• in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips
• to study its effects as an endocrine disruption inducer in Pimephales promelas

生物化学的／生理学的作用

Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.

Selective serotonin reuptake inhibitor.

特徴および利点

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H318
• 注意書き: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves