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主要文書

EHU074041

MISSION^® esiRNA

Name: MISSION<SUP>®</SUP> esiRNA
Brand: SIGMA

targeting human PRKAA1

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About This Item

UNSPSCコード:

41105324

NACRES:

NA.51

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Sigma-Aldrich

EHU114431

MISSION^® esiRNA

Sigma-Aldrich

123041

AICA-Riboside, 5′-Phosphate

DWK209164

Wheaton^® Leak Resistant Bottle

Sigma-Aldrich

SML2345

Rhynchophylline

DWK209550

Wheaton^® Leak Resistant Bottle

Sigma-Aldrich

HPA029901

Anti-SOX4 antibody produced in rabbit

Sigma-Aldrich

SIC001

MISSION^® siRNA Universal Negative Control #1

Sigma-Aldrich

123040

AICA-Riboside

Millipore

YT310RAHW

Millipore Rotary Agitator, 115 V/60 Hz

Sigma-Aldrich

07-224

抗リン酸化STAT2（Tyr689）抗体

詳細

品質水準

100

製品種目

MISSION^®

フォーム

lyophilized powder

esiRNA cDNA標的配列

TGCTCAGAAGAGGAAGTTCTCAGCTGTCTTTACAACAGAAATCACCAGGATCCTTTGGCAGTTGCCTACCATCTCATAATAGATAACAGGAGAATAATGAATGAAGCCAAAGATTTCTATTTGGCGACAAGCCCACCTGATTCTTTTCTTGATGATCATCACCTGACTCGGCCCCATCCTGAAAGAGTACCATTCTTGGTTGCTGAAACACCAAGGGCACGCCATACCCTTGATGAATTAAATCCACAGAAATCCAAACACCAAGGTGTAAGGAAAGCAAAATGGCATTTAGGAATTAGAAGTCAAAGTCGACCAAATGATATTATGGCAGAAGTATGTAGAGCAATCAAACAATTGGATTATGAATGGAAGGTTGTAAACCCATATTATTTGCGTGTACGAAGGAAGA

Ensembl |ヒトアクセッション番号

ENSG00000132356

NCBIアクセッション番号

NM_006251

輸送温度

ambient

保管温度

−20°C

遺伝子情報

human ... PRKAA1(5562) , PRKAA1(5562)

詳細

MISSION^® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

法的情報

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類コード

10 - Combustible liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable

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Targeting PP2A activates AMPK signaling to inhibit colorectal cancer cells.

Cuiping Dai et al.

Oncotarget, 8(56), 95810-95823 (2017-12-10)

LB-100 is a novel PP2A inhibitor. Its activity in human colorectal cancer (CRC) cells was tested. The

Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer.

Xue Han et al.

Oncogene, 38(38), 6537-6549 (2019-07-31)

Endometrial cancer (EC) is one of the most common gynecologic malignancies. However, the molecular mechanisms underlying the development and progression of EC remain unclear. Here, we demonstrated that the protein proviral insertion in murine lymphomas 2 (PIM2) was necessary for

Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.

Takuma Hashimoto et al.

Biochemical and biophysical research communications, 505(1), 13-19 (2018-09-19)

Solid tumors often contain hypoxic regions because an abnormal and inefficient tumor vasculature is unable to supply sufficient oxygen. Tissue hypoxia is generally defined as a low oxygen concentration of less than 2%. It is well known that tumor cells

AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation.

Ying-Nan Wang et al.

Oncogene, 39(3), 637-650 (2019-09-19)

Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the variation remain unclear. Here we show that AMPKα1 is

Curcumin enhances LXRα in an AMP-activated protein kinase-dependent manner in human macrophages.

Javier Sáenz et al.

The Journal of nutritional biochemistry, 54, 48-56 (2017-12-16)

Liver X receptor alpha (LXRα) is a nuclear receptor involved in cholesterol homeostasis. Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well-known AMP-activated protein kinase (AMPK) activator, possess hypocholesterolemic activity, however, the possible link between

主要文書

MISSION^® esiRNA