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由来生物
goat
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
交差性
human
テクニック
western blot: 1 μg/mL
UniProtアクセッション番号
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
SMILES記法
CCCCCCCC/C=C/CCCCCCCCCC(OC(CCCCCCCC/C=C/CCCCCCCCC)=O)=O
InChI
1S/C40H74O3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(41)43-40(42)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17,19-20,22H,3-16,18,21,23-38H2,1-2H3/b19-17+,22-20+
InChI Key
WOPZJDCVLPFUEY-ZEYSCXRRSA-N
遺伝子情報
human ... EPOR(2057)
詳細
Erythropoietin Receptor (EPO R) is a protein that belongs to type I cytokine receptor superfamily and is expressed mainly in megakaryocytes, erythoid progenitors, endothelial cells and neurons. Erythropoietin binds to EPO receptor and stimulates Jak2 tyrosine kinase which in turn phosphorylate tyrosine residue of EPO receptor and results in activation of several intracellular pathways (Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors). Anti-Erythropoietin Receptor antibody can be used for analyzing the neurite outgrowth. Goat anti-Erythropoietin Receptor antibody reacts specifically with recombinant human erythropoietin receptor.
免疫原
NSO細胞で発現させたリコンビナントヒトエリスロポエチン可溶性レセプタ-。
アプリケーション
Anti-Erythropoietin Receptor can be used in western blotting at a working antibody concentration of 1 μg/ml for detecting human EPO receptor.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunocytochemistry (1 paper)
物理的形状
凍結乾燥品 (PBS溶液, 5%トレハロ-ス含有, 0.2μmフィルタ-滅菌済み)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
13 - Non Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
E4644-BULK:
E4644-.1MG-PW:
E4644-VAR:
E4644-.1MG:
The erythropoietin receptor and the molecular basis of signal transduction.
D L Barber et al.
Seminars in hematology, 29(4), 293-304 (1992-10-01)
Stanislava Pankratova et al.
Journal of neurochemistry, 121(6), 915-923 (2012-04-04)
Apart from its hematopoietic activity, erythropoietin (EPO) is also known as a tissue-protective cytokine. In the brain, EPO and its receptor are up-regulated in response to insult and exert pro-survival effects. EPO binds to its receptor (EPOR) via high- and
Structure, function, and activation of the erythropoietin receptor.
H Youssoufian et al.
Blood, 81(9), 2223-2236 (1993-05-01)
Erythropoietin receptors: their role beyond erythropoiesis.
Jerome Rossert et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 20(6), 1025-1028 (2005-04-21)
María José Vázquez-Mellado et al.
Oncology reports, 41(2), 1333-1341 (2018-11-30)
Erythropoietin (Epo) is used for the treatment of cancer‑associated anaemia. However, certain studies have identified that the administration of Epo mediates the acquisition of resistance to cisplatin, which is widely used to treat cervical cancer. Our group previously reported that
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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