D9944

Monoclonal Anti-DYNLT1 antibody produced in mouse

~1.0 mg/mL, clone T1, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-CW-1, Anti-Dynein, light chain, Tctex-type 1, Anti-TCTEL1, Anti-Tctex-1
• UNSPSCコード: 12352203
• NACRES: NA.41
• クローン: T1, monoclonal
• application: ICC; WB
• 化学種の反応性: monkey, mouse, bovine, human, rat
• テクニック: immunocytochemistry: suitable; western blot: 8-16 μg/mL using NRK total cell lysate
• citations: 9

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: T1, monoclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~12.5 kDa
• 化学種の反応性: monkey, mouse, bovine, human, rat
• 濃度: ~1.0 mg/mL
• テクニック: immunocytochemistry: suitable; western blot: 8-16 μg/mL using NRK total cell lysate
• アイソタイプ: IgG1
• UniProtアクセッション番号: P63172
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... DYNLT1(6993) ; mouse ... Dynlt1(21648) ; rat ... Dynlt1(83462)

詳細

免疫原

recombinant dynein 1 light chain-myosin basic protein fusion protein.

アプリケーション

Monoclonal Anti-DYNLT1 antibody produced in mouse is suitable for immunocytochemistry and immunoblotting at a working concentration of 8-16μg/mL using NRK total cell lysate.

生物化学的／生理学的作用

Cytoplasmic dynein motor complex is responsible for minus-end, microtubule-based motile processes. It is thus involved in a wide range of eukaryotic cellular processes including trafficking of membranal vesicles, viruses and other intracellular particles. DYNLT1 is a light chain subunit of the complex that is involved in cargo binding. It binds specifically to the cytoplasmic tail of rhodopsin and links rhodopsin-bearing vesicles to the dynein motor complex for transport. The cargo is released by the disassembly of dynein complex upon phosphorylation of DYNLT1 on Ser⁸² residue. This process is critical for the apical delivery of membrane cargoes. It also mediates neurite extension by modulating actin dynamics and also Rac1 activity. The abundance and expression pattern of DYNLT1 in neuronal tissues may also contribute to the invasion capabilities of neurotropic viruses like poliovirus.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)