おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
化学種の反応性
human, rat
テクニック
western blot: 1:1,000 using rat brain cytosol extract
western blot: 1:1,000 using whole extract of the human epitheloid carcinoma HeLa cell line
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... DBN1(1627)
rat ... Dbn1(81653)
詳細
Drebrin is a member of the newly identified ADF-H family of actin-binding proteins that share the structurally conserved actin-depolymerizing factor (ADF) binding module. It is composed of a single ADF-H domain at its N-terminus, followed by a non-conserved central region and a C-terminal SH3 domain. Three isoforms, E1 and E2 (embryonic) and A (adult), have been identified in the brain. An additional truncated form of drebrin A, s-drebrin/A2, is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
免疫原
ヒトドレブリンE/AのN末端領域(アミノ酸22~42)に相当する合成ペプチドのKLH結合体。
生物化学的／生理学的作用
Drebrin (developmentally-regulated brain protein) is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. It colocalizes with actin filaments and dendritic-like cell processes and may be involved in actin remodeling. It binds to and dissociates F-actin stabilizing proteins such as α-actinin, fascin, and tropomyosin from actin filaments. It plays an important role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain.
物理的形状
0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
D3816-VAR:
D3816-BULK:
D3816-200UL:
IXO11409:
最新バージョンのいずれかを選択してください：
The ADF homology (ADF-H) domain: a highly exploited actin-binding module.
P Lappalainen et al.
Molecular biology of the cell, 9(8), 1951-1959 (1998-08-07)
Stephen W Scheff et al.
Neurobiology of aging, 42, 1-12 (2016-05-05)
Neuritic amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD) and are major components used for the clinical diagnosis of this disorder. However, many individuals with no cognitive impairment (NCI) also present at autopsy with high levels of
No overt deficits in aged tau-deficient C57Bl/6. Mapttm1 (EGFP) Kit GFP knockin mice
Van Hummel A, et al.
PLoS ONE, 11, e0163236-e0163236 (2016)
11991718
10th Internatl. Conf. on Organic Synthesis, Bangalore, India, December 1994 null
H Asada et al.
Journal of neuroscience research, 38(2), 149-159 (1994-06-01)
Drebrins are developmentally regulated actin-binding proteins. In this study, we analyzed subcellular distribution of drebrin E in neuroblastoma cells (SH-SY5Y) in culture, especially in terms of its relationship to actin filaments. In undifferentiated cells, drebrin E was scattered as flocculus
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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