C7479

抗カルレチニン ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-CAB29, Anti-CAL2, Anti-CR
• MDL番号: MFCD01321794
• UNSPSCコード: 12352203
• NACRES: NA.44

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 29 kDa
• 化学種の反応性: rat, human, chicken
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using formalin-fixed, paraffin-embedded rat cerebellum sections; microarray: suitable; western blot: 1:1,000 using recombinant human calretinin
• UniProtアクセッション番号: P22676
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CALB2(794) ; rat ... Calb2(117059)

詳細

詳細

Anti-Calretinin is developed in rabbit using a synthetic peptide corresponding to the C-terminal region of rat calretinin (amino acids 194-209) conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Calretinin is an intracellular Ca²⁺-binding protein, with broad tissue distribution and is a member of the calmodulin superfamily. It is expressed in certain populations of neurons in the central and peripheral nervous systems. It is abundant in the cerebellum (granule cells), olfactory bulb and auditory pathways.

免疫原

ラットカルレチニンのC末端領域(アミノ酸194-209)に相当する合成ペプチドのKLH結合体。免疫原の配列はカルレチニンに特異的であり、カルビンジンD-28K, カルビンジンD-9K, ミオシン軽鎖, パルブアルブミン, S-100a, S-100b, S-100A2(S100L), S100A6(カルサイクリン)など他のEF-ハンドファミリ-の分子には認められません。この配列はヒト, マウスカルレチニンで同一であり、ニワトリカルレチニンで高度に保存されています。

アプリケーション

Anti-Calretinin antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.

Anti-Calretinin antibody produced in rabbit is suitable for the following applications:

• immunohistochemistry
• microarray
• western blotting at a dilution of 1:1,000 using recombinant human calretinin

生物化学的／生理学的作用

The physiological function of calretinin is not known, but it seems to be related to Ca²⁺ buffering and diffusion. Calretinin-deficient mice show impaired long-term potentiation (LTP) in the dentate gyrus, impaired motor coordination and Purkinje cell excitability. A role for both calretinin and calbindin-D-28K in synaptic plasticity and in neuroprotection from excitotoxic insults has been postulated. By acting as a buffer or sensor of intracellular free Ca²⁺, calretinin promotes calcium homeostasis. Furthermore, several truncated forms of calretinin have been found in certain tumor cells, but are absent from normal cells, suggesting that calretinin may play a role in tumorigenesis.

物理的形状

0.01M PBS溶液(pH 7.4, 1% BSA, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable