C4801

シクロ(7-アミノヘプタノイル-Phe-D-Trp-Lys-Thr[Bzl])

≥95% (HPLC), powder

• 別名: シクロソマトスタチン
• 実験式（ヒル表記法）: C₄₄H₅₇N₇O₆
• CAS番号: 84211-54-1
• 分子量: 779.97
• MDL番号: MFCD00076778
• UNSPSCコード: 12352200
• PubChem Substance ID: 24892727
• NACRES: NA.32

特性

• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 色: white
• 溶解性: H₂O: 1 mg/mL, clear, colorless
• 保管温度: −20°C
• SMILES記法: O=C(N[C@H](C(N[C@@]1([H])[C@@H](C)OCC2=CC=CC=C2)=O)CCCCN)[C@H](NC([C@@H](NC(CCCCCCNC1=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=C4C=CC=C5
• InChI: 1S/C44H57N7O6/c1-30(57-29-32-18-8-5-9-19-32)40-44(56)46-25-15-3-2-10-23-39(52)48-37(26-31-16-6-4-7-17-31)42(54)50-38(27-33-28-47-35-21-12-11-20-34(33)35)43(55)49-36(41(53)51-40)22-13-14-24-45/h4-9,11-12,16-21,28,30,36-38,40,47H,2-3,10,13-15,22-27,29,45H2,1H3,(H,46,56)(H,48,52)(H,49,55)(H,50,54)(H,51,53)/t30-,36+,37+,38-,40+/m1/s1
• InChI Key: YHVHQZYJGWGAKN-ZUWUZHNASA-N
• 遺伝子情報: human ... SST(6750) ; mouse ... SST(20604) ; rat ... SST(24797)

詳細

Amino Acid Sequence

cyclo-Phe-Trp-Lys-Thr-Bzl

アプリケーション

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .

生物化学的／生理学的作用

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and corticotropin-releasing factor-induced suppression of gastric emptying.

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), also known as cyclosomatostatin. Inhibition of somatostatin receptors by cyclosomatostatin induces catalepsy in rats.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)